PMID:
Immunopharmacol Immunotoxicol. 2019 Feb ;41(1):55-67. Epub 2018 Dec 12. PMID: 30541359
Abstract Title:
Phyllanthin and hypophyllanthin fromameliorates immune-inflammatory response in ovalbumin-induced asthma: role of IgE, Nrf2, iNOs, TNF-α, and IL's.
Abstract:
Asthma is a chronic airway immunoinflammatory disorder characterized by airway remodeling.has been reported to possess antioxidant and anti-inflammatory potential.To evaluate the possible mechanism of action of isolated phytoconstituents from(PA) against ovalbumin (OVA)-induced experimental airway hyperresponsiveness (AHR).Phyllanthin and hypophyllanthin were isolated and characterized (HPLC) from the methanolic extract of PA. AHR was induced in Sprague-Dawley rats by OVA-challenged, and animals were treated with PA (50, 100, and 200 mg/kg, p.o.) for 28 days.The HPLC analysis showed the presence of phyllanthin and hypophyllanthin in methanolic extract of PA at RT of 25.243 and 26.832 min, respectively. OVA-induced alterations in hemodynamic parameters, lung functions test, peripheral blood oxygen level, total, and differential cell count in Bronchoalveolar Lavage Fluid was significantly attenuated (
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