PMID:
Indian J Hematol Blood Transfus. 2018 Apr ;34(2):268-272. Epub 2017 Sep 30. PMID: 29622868
Abstract Title:
Bufalin Enhances the Cytotoxity of Human Multiple Myeloma Cells H929 to AKT Inhibitor MK2206: The Role of Protein AKT Phosphorylation.
Abstract:
This study was purposed to investigate bufalin combined with AKT inhibitor MK2206 on growth inhibition and apoptosis of multiple myeloma cell line H929. CCK-8 assay and Annexin/PI staining were used to access the effects of bufalin and MK2206 in single or in combination, on inhibition of proliferation and induction of apoptosis in H929 cells. The apoptotic cells markedly increased after treated with nM bufalin andμM MK2206, including caspase3 and PARP1 proteins activated. The difference was statistically significant (
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