PMID:
Br J Nutr. 2020 Jan 29:1-24. Epub 2020 Jan 29. PMID: 31992372
Abstract Title:
Flaxseed oil in the context of a weight loss program ameliorates fatty liver grade in patients with non-alcoholic fatty liver disease: a randomized double-blind controlled trial.
Abstract:
Long-chain omega-3 fatty acids have shown to regulate lipid metabolism and reduce fat accumulation in the liver. This trial investigated the effect of flaxseed oil, as a rich source of alpha-linolenic acid, on fatty liver and cardiometabolic risk factors in patients with non-alcoholic fatty liver disease (NAFLD). The randomized, double-blind, controlled trial was performed on 68 NAFLD patients who divided into flaxseed (n=34) and sunflower (n=34) oil groups. Patients were given a hypocaloric diet (-500 kcal/d) and 20 g/d of the corresponding oil for 12 weeks. Fatty liver grade, liver enzymes, and cardiometabolic parameters were determined. The intention-to-treat approach was used for data analysis. Fatty liver grade significantly decreased in both groups (-0.68 in flaxseed vs. -0.29 in sunflower, P=0.002). ALT and AST decreased in both groups (P
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