The present study suggested that chrysin may be useful for the management of depressant-like effects induced by chronic stress.

PMID: 

Cardiovasc Hematol Disord Drug Targets. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31237217

Abstract Title: 

The effects of chrysin on serum corticosterone levels and brain oxidative injury induced by immobilization in rat.

Abstract: 

The current study was designed to investigate the effects of chrysin (CH) on serum corticosterone level. We also investigated depression-like behavior induced by chronic restraint stress in rats. The rats were kept in restrainers for 1 hour daily for 21 consecutive days. Then, the animals were daily injected with either vehicle or CH (10, 20, 30µg/kg) for 21 days. Our findings showed that the serum corticosterone levels significantly increased in rats submitted to the restraint stress versus non-stressed animals (p

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