PMID:
Chest. 2020 Feb ;157(2):e21-e23. PMID: 32033656
Abstract Title:
Vitamin C Deficiency-Induced Pulmonary Arterial Hypertension.
Abstract:
We report a case of a man in his 60s who developed pulmonary arterial hypertension (PAH) in association with profound vitamin C deficiency. Decreased availability of endothelial nitric oxide and activation of the hypoxia-inducible family of transcription factors, both consequences of vitamin C deficiency, are believed to be mechanisms contributing to the pathogenesis of the pulmonary hypertension. The PAH resolved following vitamin C supplementation. The current case highlights the importance of testing for vitamin C deficiency in patients with PAH in the proper clinical setting.
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