Vitamin C and thiamine is associated with increased survival in septic ICU patients.

PMID: 

J Trauma Acute Care Surg. 2020 Feb 7. Epub 2020 Feb 7. PMID: 32039973

Abstract Title: 

Vitamin C and Thiamine Are Associated with Lower Mortality in Sepsis.

Abstract: 

INTRODUCTION: The efficacy of vitamin C (VitC) and thiamine (THMN) in patients admitted to the intensive care unit (ICU) with sepsis is unclear. The purpose of this study was to evaluate the effect of VitC and THMN on mortality and lactate clearance in ICU patients. We hypothesized that survival and lactate clearance would be improved when treated with thiamine and/or vitamin C.METHODS: The Philips eICU database version 2.0 was queried for patients admitted to the ICU in 2014-2015 for≥48 hours and patients with sepsis and an elevated lactate≥2.0 mmol/L. Subjects were categorized according to the receipt of VitC, THMN, both, or neither. The primary outcome was in-hospital mortality. Secondary outcome was lactate clearance defined as lactate

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