PMID:
Rom J Morphol Embryol. 2019 ;60(3):921-929. PMID: 31912105
Abstract Title:
Red grape juice protects the rat thyroid gland against hypercholesterolemic changes. Ultrastructural and biochemical evidences.
Abstract:
OBJECTIVES: This study aimed to assess the impact of high cholesterol diet (HCD)-induced hypercholesterolemia on the rat thyroid gland and investigate the role of grape juice (GJ) in reducing such impact through biochemical and histopathological methods.MATERIALS AND METHODS: Thirty male Wistar rats sorted into three groups (the control, HCD-fed group, and the HCD+GJ fed group for 13 weeks) were used in this study. Lipid profile, blood glucose and insulin, thyroid hormones, some oxidants/antioxidants parameters were assessed. After the end of the experiment, thyroid glands were dissected out and processed for histopathological assessment using the light and electron microscopy.RESULTS: Based on the lipid profile, HCD induced hypercholesterolemia in rats after 13 weeks. This resulted in significant (p
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