PMID:
J Ethnopharmacol. 2020 Mar 1 ;249:112416. Epub 2019 Nov 19. PMID: 31756448
Abstract Title:
Dietary supplementation of Morus nigra L. leaves decrease fat mass partially through elevating leptin-stimulated lipolysis in pig model.
Abstract:
ETHNOPHARMACOLOGICAL RELEVANCE: Mulberry leaves are the dry leaves of Morus nigra L. trees, which are widely cultivated in central and southern China. Mulberry has a long history of medicinal use, such as anti-stress, lowering blood glucose and anti-obesity.AIM OF THE STUDY: Explore the effects of mulberry leaves on fat deposition as well as the underlying mechanisms.MATERIALS AND METHODS: Total of 48 fattening pigs weighing about 70 kg were randomly allotted to normal diet or die supplemented with 5% (w/w) mulberry leave powder. Changes of fat mass, indicated by backfat thickness was measured with Piggyback tester, blood triglyceride and cholesterol were tested using commercial biochemical kits, serum hormones were estimatedby ELISA, and leptin-related signaling activity were assessed using western-blot.RESULTS: Supplementation with Mulberry leaf feed (MF) significantly reduced serum triglyceride and free cholesterol concentrations and increased the ratio of high-density lipoprotein cholesterol (HDL-c) to low-density lipoprotein cholesterol (LDL-c), while serum glucose and free fatty acids remained unchanged. Dietary MF resulted in a significant reduction in the size of adipocytes and backfat thickness (P
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