PMID:
PLoS One. 2020 ;15(2):e0229029. Epub 2020 Feb 14. PMID: 32059038
Abstract Title:
Gut dysbiosis is prevailing in Sjögren's syndrome and is related to dry eye severity.
Abstract:
OBJECTIVE: To investigate gut dysbiosis in patients with Sjögren's syndrome (SS) or dry eye syndrome (DES) compared to normal subjects and to evaluate the association of dysbiosis with dry eye severity.METHODS: 10 subjects with SS, 14 subjects with DES and 12 controls were enrolled. Corneal staining, tear break up time (TBUT) and tear secretion were evaluated. Bacterial genomic 16s rRNA from stool samples were analyzed. Main outcomes were microbiome compositional differences among groups and their correlation to dry eye signs.RESULTS: Gut microbiome analysis revealed significant compositional differences in SS compared to controls and DES. In phylum, Bacteriodetes increased, while Firmicutes/Bacteroidetes ratio and Actinobacteria decreased (p
Health Time 