PMID:
Comb Chem High Throughput Screen. 2020 Feb 19. Epub 2020 Feb 19. PMID: 32072893
Abstract Title:
Favorable Effects of Astaxanthin on Brain Damage due to Ischemia-Reperfusion Injury.
Abstract:
BACKGROUND: Activated inflammation and oxidant stress during cerebral ischemia reperfusion injury (IRI) lead to brain damage. Astaxanthin (ASX) is a type of carotenoid with a strong antioxidant effect.OBJECTIVE: The aim of this study was to investigate the role of ASX on brain IRI.METHODS: A total of 42 adult male Sprague-Dawley rats were divided into 3 groups as control (n=14) group, IRI (n=14) group and IRI + ASX (n=14) group. Cerebral ischemia was instituted by occluding middle cerebral artery for 120 minutes and subsequently, reperfusion was performed for 48 hours. oxidant parameter levels and protein degradation products were evaluated. Hippocampal and cortex cell apoptosis, neuronal cell count, neurological deficit score were evaluated.RESULTS: In the IRI group, oxidant parameter levels and protein degradation products in the tissue were increased compared to control group. However, these values were significantly decreased in the IRI + ASX group (p
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