PMID:
J Cosmet Dermatol. 2020 Feb ;19(2):529-534. Epub 2019 Jul 2. PMID: 31267657
Abstract Title:
Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice.
Abstract:
BACKGROUND & AIM: Panax notoginseng saponins are believed to promote wound healing due to its anti-proliferative effect on fibroblasts. The present work was therefore aimed to examine the beneficial effect of PNS on wound healing in vitro and in a murine model of cutaneous wound.METHODS: The in vitro effects of Panax notoginseng saponins on the proliferation of and nitric oxide (NO) synthesis in human fibroblast 3T3 cells were studied. The in vivo effects of Panax notoginseng saponins were examined in C57 mice with dorsal cutaneous wound. The healing rate and scar formation were followed after treatment with Panax notoginseng saponins. The histology and fibroblast accumulation in the wounds were studied using hematoxylin and eosin (H&E) staining. Expression ofα-smooth muscle actin (α-SMA) was examined by immunohistochemistry.RESULTS: Panax notoginseng saponins inhibited the proliferation of human fibroblast 3T3 with an ECof 1.825 mM Panax notoginseng saponins (0.1 mM) significantly promoted NO production (P
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