PMID:
J Appl Microbiol. 2014 Nov ;117(5):1388-99. Epub 2014 Oct 3. PMID: 25175797
Abstract Title:
Sodium ascorbate as a quorum sensing inhibitor of Pseudomonas aeruginosa.
Abstract:
AIMS: Quorum sensing circuits regulate virulence factors in Pseudomonas aeruginosa and coordinate bacterial pathogenicity. We are interested in exploring available medications for their antiquorum sensing activity.METHODS AND RESULTS: First, we determined the MIC of ascorbate against Ps. aeruginosa strain PAO1, and all further experiments used concentrations below the MIC so that results could not be caused by reduced viability. Tests of subinhibitory concentrations of sodium ascorbate on cell signals were performed using a reporter strain assay. Sub-MICs of sodium ascorbate resulted in significant reduction of the signalling molecules C4-HSL and 3-oxo-C12-HSL (P
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