Anti-diabetic compounds from the seeds of Psoralea corylifolia.

PMID: 

Fitoterapia. 2019 Nov ;139:104373. Epub 2019 Oct 16. PMID: 31629053

Abstract Title: 

Anti-diabetic compounds from the seeds of Psoralea corylifolia.

Abstract: 

A new aurone named (2Z)-2-[(4'-hydroxyphenyl) methylene]-6-hydroxy-7-prenyl-3(2H)-benzofurane (1), two new flavonoids named (2S)-7-methoxy-6-(2-hydroxy-3-methylbut-3-en-1-yl)-2-(4-hydroxyphenyl)chroman-4-one (2), (2S)-4'-hydroxyl-7-hydroxymethylene-6-(2″,3″-epoxy-3″-methylbutyl)flavanone (3), and a new coumestan named bavacoumestan E (4), together with eleven known compounds (5-15), were isolated from the seeds of Psoralea corylifolia. The chemical structures were elucidated by spectroscopic and physico-chemical analyses. All isolates were evaluated for in vitro inhibitory activity against DGAT, PTP1B and α-glucosidase. Compounds 1, 2 and 3 showed potential inhibitory activities on DGAT1 with ICvalues of 35.2 ± 1.3, 51.3 ± 1.1 and 43.4 ± 0.7 μM, respectively. Compounds 6 and 8 displayed the significant inhibitory activities on α-glucosidase with ICvalue of 28.0 and 23.0 μM, respectively.

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