PMID:
Int J Cancer. 2004 Sep 1 ;111(3):398-403. PMID: 15221967
Abstract Title:
Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy.
Abstract:
In this work, we investigated the anticancer activity of orally administered recombinant human lactoferrin (rhLF) alone and in combination with chemotherapy in tumor-bearing mice. rhLF inhibited the growth of squamous cell carcinoma (O12) tumors in T cell-immunocompromised nu/nu mice by 80% when administered at 1,000 mg/kg (2.9 g/m2) by oral gavage twice daily for 8 days (p