PMID:
Turk J Med Sci. 2020 Feb 25. Epub 2020 Feb 25. PMID: 32093448
Abstract Title:
Neuroprotective Effects of Quercetin on Cerebral Vasospasm Following Experimental Subarachnoid Haemorrhage in Rats.
Abstract:
BACKGROUND: We examined the protective effects of the natural flavonoid, quercetin, against cerebral vasospasm in an experimental rat subarachnoid haemorrhage (SAH) model.MATERIALS AND METHODS: Thirty-eight albino Wistar rats were divided into five groups as follows: group 1 (G1, n=8), no experimental intervention; group 2 (G2, n=8), subarachnoid physiological saline; group 3 (G3, n=8), SAH; group 4 (G4, n=7) SAH and low-dose (10 mg/kg) quercetin treatment; group 5 (G5, n=7), SAH and high-dose (50 mg/kg) quercetin treatment. Subarachnoid haemorrhage was induced by injection of 0.15 cc of autologous blood taken from the tail artery into the cisterna magna from the craniocervical junction and basilar arteries and blood samples were taken for biochemical and histopathological analyses.RESULTS: Malondialdehyde (MDA) levels were significantly higher in G2 and G3 than in G1 (p
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