PMID:
J Agric Food Chem. 2020 Feb 22. Epub 2020 Feb 22. PMID: 32090563
Abstract Title:
Neuroprotection by Walnut-derived Peptides through Autophagy Promotion via Akt/mTOR Signaling Pathway against Oxidative Stress in PC12 Cells.
Abstract:
Natural-derived peptides are effective substances in attenuating oxidative stress. However, their specific mechanisms have not been fully elucidated, especially in peptide-mediated autophagy. In the present study, TWLPLPR, YVLLPSPK, and KVPPLLY, novel peptides fromMaxim, prevented ROS production, elevated GSH-Px activity and ATP levels, and ameliorated apoptosis in Aβ(at concentration of 50μM for 24 h) induced PC12 cells (
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