PMID:
J Diabetes Metab Disord. 2019 Dec ;18(2):505-512. Epub 2019 Nov 19. PMID: 31890676
Abstract Title:
Effect of ethanolic preparations of cinnamon () extract on hematologic and histometric parameters of selected organs in Alloxaninduced diabetic female albino rats.
Abstract:
Purpose: Assessment of the antidiabetic effect of cinnamon bark extract in histologic damages and some hematologic parameters in Alloxan® induced diabetic female albino rats.Method: Thirty female albino rats weighing 150-230 g were divided into five groups ( = 6): normal (G1) and diabetic groups (intraperitoneally Alloxan®-injected) including diabetic control (G2), Getformin @ 0.25 (G3), CE @ 0.10 (G4), and CE @ 0.20 g/kg b.wt. (G5) for 49 days. Blood glucose level and weight were measured on weekly interval for the period of seven weeks (49th day). Blood samples were collected for hematologic analysis. Tissue samples from uterus, liver and kidneys were processed by routine paraffine technique. Histologic sections of uterus were studied to measure endometrial glands area and thickness of endo- and myometrium. Liver and kidneys were evaluated for diabetes-induced degenerative changes and antidiabetic effect of cinnamon extract (CE). One-way analysis of variance followed by Tukey test were used to compare the group means for each parameter.Results: Statistical analysis revealed significant (
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