PMID:
Int J Clin Pract. 2020 Feb 24:e13493. Epub 2020 Feb 24. PMID: 32091656
Abstract Title:
Alpha-Lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomized-placebo controlled clinical trials.
Abstract:
BACKGROUND: There are numerous trials reported the effect of ALA on obesity measurements; while no summarized dose-response meta-analysis is available to address the effects of dose and duration of ALA supplementation on obesity measurements. We aimed to summarize the results of studies evaluating the effects of ALA supplementation on obesity measurements in a systematic review and dose-response meta-analysis.METHODS AND MATERIALS: In a systematic search from Scopus, PubMed, Embase, Proquest electronic databases up to January 2020 relevant studies were retrieved. Randomized, placebo-controlled trials investigating the effect of ALA supplementation on obesity measurements including weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR) and fat mass (FM) were included. Two class and dose-response meta-analysis were performed to data analysis.RESULTS: Totally, eighteen, twenty one and eight studies were included for the meta-analysis of ALA-weight, ALA-BMI, ALA-WC respectively. In the two-class meta-analysis, ALA treatment significantly reduced weight (WMD: -2.29 kg, 95% CI: -2.98, 1.60, P
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