Buddleja saligna Willd chelates iron, inhibits angiotensin-converting enzyme, acetylcholinesterase, and lipase, and modulates serum lipids and metabolic pathways in vitro.

PMID: 

J Ethnopharmacol. 2020 Feb 10 ;248:112358. Epub 2019 Oct 30. PMID: 31676404

Abstract Title: 

Buddleja saligna Willd (Loganiaceae) inhibits angiotensin-converting enzyme activity in oxidative cardiopathy with concomitant modulation of nucleotide hydrolyzing enzymatic activities and dysregulated lipid metabolic pathways.

Abstract: 

ETHNOPHARMACOLOGICAL RELEVANCE: Buddleja saligna Willd (Loganiaceae), mostly indigenous to South Africa is traditionally used in the treatment cardio-dysfunctional related ailments amongst other diseases.AIMS: The cardio-protective effect of B. saligna was investigated in ferric-induced oxidative cardiopathy.METHODS: Hearts harvested from healthy male SD rats were incubated with 0.1 mM FeSOto induce oxidative damage and co-incubated with B. saligna extract. Reaction mixtures without the extract served as negative control, while tissues without the extract or standard antioxidant (gallic acid) and pro-oxidant served as the normal control. The tissues were analyzed for levels of glutathione, malondialdehyde, and nitric oxide as well as cholinergic, angiotensin-converting enzyme (ACE), lipase, and purinergic enzymes activities, lipid profiles, fatty acid metabolic pathways and metabolites.RESULTS: Induction of oxidative damage significantly (p 

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