PMID:
Biomed Res Int. 2020 ;2020:6583603. Epub 2020 Feb 27. PMID: 32190675
Abstract Title:
Cardiac Ameliorative Effect ofLeaf Extract in High-Fat Diet-Induced Obesity in Rat Model.
Abstract:
The consumption of a high-fat diet is linked to the development of obesity and considered a risk factor for cardiovascular diseases. The aim of this study was to evaluate the effect of the methanolic extract ofleaves (MEML) on the high-fat diet- (HFD-) induced obesity and cardiac damage in rats. MEML, at a dose of 200 mg/kg/bw and 400 mg/kg/bw, was orally administrated to obese rats for 12 weeks..leaves were proved to be rich in nutrients and minerals. Diversity of phenolic compounds in MEML was evidenced via LC-ESI-MS analysis. The chronic administration of HFD in rats led to an increase in the body weight gain, total cholesterol, and triglycerides and reduction in the HDL-C levels. The obtained results indicated a significant increase (