PMID:
Pharm Biol. 2016 ;54(6):1005-13. Epub 2015 Oct 12. PMID: 26457827
Abstract Title:
The effects of Melissa officinalis (lemon balm) pretreatment on the resistance of the heart to myocardial injury.
Abstract:
CONTEXT: The antihyperlipidemic, antiarrhythmic, neuroprotective and hepatoprotective effects of Melissa officinalis L. (Lamiaceae) have been reported. However, no study has examined its effects on the resistance of the heart to stressful conditions.OBJECTIVE: The objective of this study is to evaluate the effects of aqueous extract of M. officinalis aerial parts on Wistar rat heart with/without cardiac injury.MATERIALS AND METHODS: Animals were grouped as control, isoproterenol (ISO), M. officinalis without (M50, M100, and M200) and with isoproterenol (M50 + ISO, M100 + ISO, and M200 + ISO). The aqueous extract of M. officinalis was orally administered at dosages of 50, 100, and 200 mg/kg/d, respectively, for 7 consecutive days. On the 6th and 7th day, ISO, M50 + ISO, M100 + ISO, and M200 + ISO groups received 85 mg/kg ofisoproterenol for myocardial injury induction. On day 8, hemodynamic parameters were recorded and samplings were done.RESULTS: The extract (50, 100, and 200 mg/kg) significantly reduced the heart rate (264 ± 5, 259 ± 5 and 281 ± 3 versus 377 ± 13 in control group, p
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