PMID:
Environ Sci Pollut Res Int. 2020 Jan 13. Epub 2020 Jan 13. PMID: 31933077
Abstract Title:
Protective effects of thymoquinone and diallyl sulphide against malathion-induced toxicity in rats.
Abstract:
Malathion is a potent organophosphate insecticide that inhibits acetylcholinesterase (AChE) enzyme. Our experimental objective was to investigate the beneficial effects of diallyl sulphide (DAS) and thymoquinone (TQ) against malathion-induced oxidative stress in rat cerebral, hepatic, and renal tissues. For 30 days, rats received corn oil alone (negative control) or malathion by intragastric gavage (200 mg/kg daily), either alone (positive control) or combined with oral DAS (200 mg/kg daily) or TQ (10 mg/kg daily) (treatment groups). Later, blood samples were collected via direct cardiac puncture andtissue samples were obtained for biochemical analysis. Malathion administration was associated with significant increases (p
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