PMID:
Molecules. 2019 Feb 28 ;24(5). Epub 2019 Feb 28. PMID: 30823377
Abstract Title:
Flavonoid Mixture InhibitsSurvival and Infectivity.
Abstract:
BACKGROUND: Flavonoids have been shown to exert anti-pathogenic potential, but few studies have investigated their effects on() infectivity. We hypothesized that a flavonoid mixture would have a favorable influence on cell death and the resolution ofinfection in THP-1 macrophages and in granulomas derived from both healthy participants and those with type 2 diabetes mellitus (T2DM).METHODS: THP-1 macrophages, and in vitro granulomas from healthy participants (= 8) and individuals with T2DM (= 5) were infected with. A mixed flavonoid supplement (MFS) at a concentration of 0.69 mg per ml was added as treatment toinfected THP-1 macrophages and granulomas for 8 to 15 days.RESULTS: MFS treatment significantly reduced the intracellularsurvival, increased cell density, aggregation, and granuloma formation, and increased glutathione (GSH) levels. IL-12 and IFN-γ levels tended to be higher and IL-10 lower wheninfected THP-1 macrophages and granulomas obtained from healthy subjects were treated with MFS compared to control.CONCLUSIONS: MFS treatment exerted a strong influence againstinfectivity in THP-1 macrophages and in granulomas including antimycobacterial effects, GSH enrichment, cytokine regulation, and augmented granuloma formation. Our data support the strategy of increased flavonoid intake for managing tuberculosis.
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