Lower levels of 25-OHD were found to be correlated with severity of the disease.

PMID: 

J Pediatr Gastroenterol Nutr. 2016 Mar ;62(3):479-85. PMID: 26465790

Abstract Title: 

Role of Vitamin D in Hospitalized Children With Lower Tract Acute Respiratory Infections.

Abstract: 

BACKGROUND: Vitamin D is known to have modulatory actions in the immune system. Its influence on the severity of lower tract acute respiratory infections (LT-ARIs) is unclear.OBJECTIVES: The aim of the present study was to evaluate the role of vitamin D on LT-ARI in paediatric patients.METHODS: Children admitted to hospital with LT-ARI were prospectively recruited through the GENDRES network (March 2009-May 2013). The 25-hydroxyvitamin D (25-OHD) levels were measured by immunoassay. The severity of the illness was evaluated according to clinical scales, length of hospital stay, ventilatory requirements, and pediatric intensive care unit admission.RESULTS: A total of 347 patients with a median (interquartile range) age of 8.4 (2.6-21.1) months were included. The mean (SD) 25-OHD levels in our series were 27.1 (11.3) ng/mL. In this study, a cutoff value of≥30 ng/mL was considered optimal vitamin status. Patients with 25-OHD levels

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