Vitamin C pre-treatment at different dosages could reverse at some extent the inhibitive effects of deoxynivalenol on HLA-I expression of HPBMCs.

PMID: 

Zhonghua Yu Fang Yi Xue Za Zhi. 2006 Sep ;40(5):314-8. PMID: 17166420

Abstract Title: 

[Effects of vitamin C on the inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells induced by deoxynivalenol in vitro].

Abstract: 

OBJECTIVE: To explore the putative effects of Vitamin C (Vit C) on inhibition of human leucocyte antigen class I (HLA-I) expression of human peripheral blood mononuclear cells (HPBMCs) induced by deoxynivalenol (DON) in vitro.METHODS: The effects of Vit C on the changes of HLA-I expression of HPBMCs induced by DON in vitro were evaluated with cell culture, flow cytometry (FCM), Western blotting and immunocytochemical methods.RESULTS: FCM analysis showed that HLA-I expression of HPBMCs in DON treated cells was significantly lower than that in controls (FI 0.88 +/- 0.02 vs 1.00 +/- 0.03, P

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