PMID:
Cytokine. 2004 Aug 21-Sep 7;27(4-5):101-6. PMID: 15271375
Abstract Title:
Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes.
Abstract:
BACKGROUND: Vitamin C (ascorbic acid) is an essential water-soluble nutrient which primarily exerts its effect on immune homeostasis as physiological antioxidant. However, conflicting data exist regarding the effect of vitamin C on the expression of pro-inflammatory cytokines.METHODS: It was the aim of this study to investigate the impact of vitamin C on intracytoplasmic production of pro-inflammatory cytokines in monocytes and lymphocytes by flow cytometry after human whole blood assay.RESULTS: Vitamin C dose dependently inhibited the LPS-induced number of monocytes producing IL-6 (e.g., 41.0% reduction, p
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