PMID:
Thorax. 2015 Jul ;70(7):617-24. Epub 2015 Apr 22. PMID: 25903964
Abstract Title:
Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS).
Abstract:
RATIONALE: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated.OBJECTIVES: To determine if ARDS is associated with vitamin D deficiency in a clinical setting and to determine if vitamin D deficiency in experimental models of ARDS influences its severity.METHODS: Human, murine and in vitro primary alveolar epithelial cell work were included in this study.FINDINGS: Vitamin D deficiency (plasma 25(OH)D levels600 genes. In a clinical setting, pharmacological repletion of vitamin D prior to oesophagectomy reduced the observed changes of in vivo measurements of alveolar capillary damage seen in deficient patients.CONCLUSIONS: Vitamin D deficiency is common in people who develop ARDS. This deficiency of vitamin D appears to contribute to the development of the condition, and approaches to correct vitamin D deficiency in patients at risk of ARDS should be developed.TRIAL REGISTRATION: UKCRN ID 11994.
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