PMID:
Am J Reprod Immunol. 2020 Apr 10:e13243. Epub 2020 Apr 10. PMID: 32277536
Abstract Title:
Potential impact of maternal vitamin D status on peripheral blood and endometrium cellular immunity in women with recurrent implantation failure.
Abstract:
PROBLEM: This study aims to evaluate the modulatory effects of vitamin D on peripheral blood and endometrial cellular immunity in women with recurrent implantation failure (RIF).METHOD OF STUDY: One hundred and fifty-four women with RIF were identified at a fertility center from January 2018 and March 2019. Blood and endometrium samples were collected during the mid-luteal phase before IVF treatment or pregnancy. The serum vitamin D status, NK cell cytotoxicity, Th1 cytokine production and endometrial immune cells were detected before and after vitamin D supplementation.RESULTS: The NK cell cytotoxicity at an effector-to-target (E:T) ratio of 50:1 or 25:1 was significantly higher in vitamin D insufficiency group (VDI) than those in vitamin D normal group (VDN) (P
Health Time 