PMID:
Cancer Res. 2019 Dec 1 ;79(23):5986-5998. Epub 2019 Nov 5. PMID: 31690667
Abstract Title:
Vitamin D-VDR Signaling Inhibits Wnt/β-Catenin-Mediated Melanoma Progression and Promotes Antitumor Immunity.
Abstract:
1α,25-Dihydroxyvitamin D3 signals via the vitamin D receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As patients with melanoma commonly avoid sun exposure, and consequent vitamin D deficiencymight worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role of vitamin D-VDR signaling and replicated the findings in The Cancer Genome Atlas metastases.expression was independently protective for melanoma-related death in both primary and metastatic disease. High tumorexpression was associated with upregulation of pathways mediating antitumor immunity and corresponding with higher imputed immune cell scores and histologically detected tumor-infiltrating lymphocytes. High-expressing tumors had downregulation of proliferative pathways, notably Wnt/β-catenin signaling. Deleterious lowlevels resulted from promoter methylation and gene deletion in metastases. Vitamin D deficiency (
Health Time 