PMID:
J Allergy Clin Immunol. 2019 03 ;143(3):1012-1020.e2. Epub 2018 Oct 23. PMID: 30366577
Abstract Title:
Direct infant UV light exposure is associated with eczema and immune development.
Abstract:
BACKGROUND: Suboptimal vitamin D levels during critical periods of immune development have emerged as an explanation for higher rates of allergic diseases associated with industrialization and residing at higher latitudes.OBJECTIVE: We sought to determine the effects of early postnatal vitamin D supplementation on infant eczema and immune development.METHODS: By using a double-blind randomized controlled trial, newborn infants were randomized to receive vitamin D supplementation (400 IU/d) or a placebo until 6 months of age. Some infants also wore personal UV dosimeters to measure direct UV light (290-380 nm) exposure. Infant vitamin D levels were measured at 3 and 6 months of age. Eczema, wheeze, and immune function outcomes were assessed at 6 months of age.RESULTS: At 3 (P
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