Vitamin D deficiency is associated with tuberculosis infection among household contacts in Ulaanbaatar, Mongolia.

PMID: 

Int J Tuberc Lung Dis. 2019 08 1 ;23(8):919-923. PMID: 31533882

Abstract Title: 

Vitamin D deficiency is associated with tuberculosis infection among household contacts in Ulaanbaatar, Mongolia.

Abstract: 

Vitamin D deficiency (VDD) is a known risk factor for tuberculous infection. We investigated if VDD is a risk factor for tuberculous infection among the household contacts (HHCs) of patients with tuberculosis (TB) in Mongolia.All HHCs of TB patients diagnosed in Khan-Uul District, Mongolia, were enrolled. The serum level of 25-hydroxyvitamin D [25(OH)D] was detected and TB infection determined using QuantiFERON-TB Gold Plus (QFT-Plus). A tuberculin skin test (TST) reading>10 mm was considered to be positive. Epidemiological and bacteriological data were collected from routine surveillance of the National Tuberculosis Programme.Among study participants, 48.2% (135/285) were QFT-Plus-positive. Of QFT-positive HHCs, 77.0% (104/135) were TST-positive and the overall concordance of tests was low (κ 0.374,

read more