PMID:
Parkinsonism Relat Disord. 2020 Mar 16 ;73:19-22. Epub 2020 Mar 16. PMID: 32203914
Abstract Title:
Higher vitamin B12 level at Parkinson's disease diagnosis is associated with lower risk of future dementia.
Abstract:
INTRODUCTION: To determine whether vitamin B12 level at Parkinson's disease (PD) diagnosis predicts time to develop dementia.METHODS: We utilized a population-based cohort of Parkinsonism patients to examine the relationship between serum vitamin B12 at the time of PD diagnosis and dementia risk. Receiver operating curves were calculated for vitamin B12 cutoffs maximizing sensitivity and specificity for determining who developed dementia. Time from Parkinsonism diagnosis to dementia, death, or censoring was calculated utilizing Kaplan-Meier analysis and Cox-proportional hazard models.RESULTS: PD patients who did not develop dementia had higher baseline levels of vitamin B12 at PD diagnosis (648.5 ng/L vs 452 ng/L, p
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