PMID:
Libyan J Med. 2013 Oct 7 ;8:22520. Epub 2013 Oct 7. PMID: 24103319
Abstract Title:
Rose geranium essential oil as a source of new and safe anti-inflammatory drugs.
Abstract:
BACKGROUND: Since the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries.AIMS: The aim of the present study was to assess the anti-inflammatory activities of the essential oil of rose geranium (RGEO).METHODS: The chemical composition of the RGEO was investigated by gas chromatography. The major components were citronellol (29.13%), geraniol (12.62%), and citronellyl formate (8.06%). In the carrageenan-induced paw edema, five different groups were established and RGEO was administered orally in three different doses.RESULTS: RGEO (100 mg/kg) was able to significantly reduce the paw edema with a comparable effect to that observed with diclofenac, the positive control. In addition, RGEO showed a potent anti-inflammatory activity by topical treatment in the method of croton oil-induced ear edema. When the dose was 5 or 10µl of RGEO per ear, the inflammation was reduced by 73 and 88%, respectively. This is the first report to demonstrate a significant anti-inflammatory activity of Algerian RGEO. In addition, histological analysis confirmed that RGEO inhibited the inflammatory responses in the skin.CONCLUSION: Our results indicate that RGEO may have significant potential for the development of novel anti-inflammatory drugs with improved safety profile.
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