PMID:
Int Immunopharmacol. 2018 Sep ;62:251-260. Epub 2018 Jul 20. PMID: 30032050
Abstract Title:
1, 25-dihydroxyvitamin Ddownregulates cytotoxic effector response in pulmonary tuberculosis.
Abstract:
1,25-dihydroxyvitaminD[1,25(OH)D] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)Don cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (PBMCs) from 45 healthy controls (HCs) and 45 pulmonary tuberculosis (PTB) patients were cultured with Mtb in the absence or presence of 1,25(OH)Dfor 72 h. The percentage of perforin, granulysin, and granzyme-B positive cells were estimated by flow cytometry. 1,25(OH)Dsignificantly decreased the percentage of cytolytic molecules in total, CD4+, CD8+ and CD56+ cells in HCs and PTB patients (p
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