PMID:
Steroids. 2019 10 ;150:108447. Epub 2019 Jul 11. PMID: 31302113
Abstract Title:
24R,25-dihydroxyvitamin Dmodulates tumorigenicity in breast cancer in an estrogen receptor-dependent manner.
Abstract:
Vitamin D has long been prescribed as a supplement to breast cancer patients. This is partially motivated by data indicating that low serum vitamin D, measured as 25-hydroxyvitamin D3 [25(OH)D], is associated with worsened cancer prognosis and decreased survival rates in cancer patients. However, clinical studies investigating the role of vitamin D supplementation in breast cancer treatment are largely inconclusive. One reason for this may be that many of these studies ignore the complexity of the vitamin D metabolome and the effects of these metabolites at the cellular level. Once ingested, vitamin D is metabolized into 37 different metabolites, including 25(OH)D, which is the metabolite actually measured clinically, as well as 1,25(OH)Dand 24,25(OH)D. Recent work by our lab and others has demonstrated a role for 24R,25(OH)D, in the modulation of breast cancer tumors via an estrogen receptorα-dependent mechanism. This review highlights the importance of considering estrogen receptor status in vitamin d-associated prognostic studies of breast cancer and proposes a potential mechanism for 24R,25(OH)Dsignaling in breast cancer cells.
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