PMID:
Ir J Med Sci. 2020 Apr 1. Epub 2020 Apr 1. PMID: 32239424
Abstract Title:
Therapeutic effect of N-acetylcysteine on chemotherapy-induced liver injury.
Abstract:
BACKGROUND: N-acetylcysteine (NAC) may be useful in the management of chemotherapy-induced liver injury.AIMS: The present study evaluates the possible therapeutic effects of NAC on chemotherapy-induced hepatotoxicity.METHODS: A total of 102 patients' files who were diagnosed with cancer between 2015 and 2019 were evaluated retrospectively. Two patient groups with and without NAC were selected. NAC was administered in a 3-μg/kg IV dose in a 24-h infusion to 70 patients when any alanine aminotransferase (ALT) or gamma-glutamyl transferase (GGT) values reached three times the normal levels. The other group consisted of 32 patients who were not treated with NAC. Alanine aminotransferase and GGT values were recorded atpretreatment, and on the 1st, 3rd, 5th, and 7th days in both the NAC and non-NAC groups from files.RESULTS: In the NAC group, ALT and GGT values on day 1, 3, 5, and 7 differed from each other, decreasing from day 1 to day 7. A statistically significant difference was noted between the values in the NAC group (p
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