PMID:
Nutrients. 2020 Apr 16 ;12(4). Epub 2020 Apr 16. PMID: 32316365
Abstract Title:
The Study of Correlation Between Serum Vitamin DConcentrations and HBV DNA Levels and Immune Response in Chronic Hepatitis Patients.
Abstract:
Chronic hepatitis B (CHB) is a common chronic disease. Previous studies have shown a link between 25-hydroxyvitamin D(vitamin D) concentration and liver disease. Hepatitis B virus (HBV) infection has been attributed to the inappropriate functioning of cell-mediated immunity. However, the effects of vitamin D, immune cell, and HBeAg status on HBV viral load in CHB patients are still unclear. We investigated the relationship between the serum concentration of vitamin D, percentage of immune cells in peripheral blood, and the HBV viral load of CHB patients. Sixty CHB patients were recruited, and their blood samples were collected and analyzed. Vitamin D level was measured using a chemiluminescence assay. A level of 30 ng/mL or above was defined as a vitamin Dsufficiency. We assigned vitamin Dstatus as either normal (≥30 ng/mL), insufficient (20-30 ng/mL), or deficient (
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