PMID:
Int J Mol Sci. 2019 Oct 24 ;20(21). Epub 2019 Oct 24. PMID: 31653116
Abstract Title:
The Positive Effects ofHeteropolysaccharide on NAFLD and Regulation of the Gut Microbiota.
Abstract:
Non-alcoholic fatty liver disease (NAFLD) is a major public health problem in many countries. In this study, the ability ofheteropolysaccharide (GFP) to ameliorate NAFLD was investigated in rats fed a high-fat diet (HFD). The molecular mechanisms modulating the expression of specific gene members related to lipid synthesis and conversion, cholesterol metabolism, and inflammation pathways were determined. The components of the intestinal microflora in rats were analyzed by high-throughput next-generation 16S rRNA gene sequencing. Supplementation with GFP significantly increased the proportions of,, andand decreased the proportions of,,,, and. In addition,,, andwere shown to be significant cecal microbiota according to the Spearman's correlation test between the gut microbiota and biomedical assays (|r|>0.7). Histological analysis and biomedical assays showed that GFP treatments could significantly protect against NAFLD. In addition,,andmay play vital roles in the prevention of NAFLD. These results suggest that GFP could be used as a functional material to regulate the gut microbiota of NAFLD individuals.
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