PMID:
J Altern Complement Med. 2020 Apr 23. Epub 2020 Apr 23. PMID: 32326727
Abstract Title:
Effect of Yoga Therapy on Disease Activity, Inflammatory Markers, and Heart Rate Variability in Patients with Rheumatoid Arthritis.
Abstract:
Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease. Antirheumatoid treatment reduces disease activity and inflammation, but not all patients respond to treatment. Autonomic dysfunction is common in RA leading to frequent cardiovascular complications. Yoga therapy may be useful in these patients, but there are little data on the effect of yoga on disease activity, inflammatory markers, and heart rate variability (HRV).This study assessed the effect of 12-week yoga therapy on disease activity, inflammatory markers, and HRV in patients with RA.This randomized control trial was conducted on newly diagnosed RA patients attending outpatient services at the Department of Clinical Immunology, JIPMER. One hundred and sixty-six participants were randomized into two groups: the control group (CG) ( = 83) and yoga group (YG) ( = 83). Yoga therapy was administered to participants in the YG for 12 weeks, along with standard medical treatment. The CG received only standard medical treatment. Primary outcomes were disease activity score 28, interleukin-1α (IL-1α), IL-6, tumor necrosis factor-α (TNF-α), cortisol, andHRV parameters. All parameters were measured at baseline and after 12 weeks.Disease activity significantly decreased in both groups after 12 weeks, but it was reduced more in YG, which was statistically significant (
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