PMID:
J Agric Food Chem. 2020 May 7. Epub 2020 May 7. PMID: 32348137
Abstract Title:
Abietane Diterpenoids with Antioxidative Damage Activity from.
Abstract:
Nine new and nineteen known compounds were isolated and identified fromunder the guidance of bioassay and LCMS. They all belonged to abietane diterpenoids which enriched the types of compounds in, especially the discovery of a series of 20-norabietane diterpenoids (,-, and-). The antioxidative damage activity of the compounds was tested on HOdamaged SH-SY5Y cells. Compounds,, andpresented moderate ability for promoting the growth of damaged cells. Compounds,,-,, anddisplayed a high antioxidative damage effect whose cell viability rates were more than 80%. The antioxidative damage effect of,,, andwere higher than that of EGCG (positive control) in which,, andwere the acetylated derivatives of carnosic acid (), 7α-methoxy-isocarnosol (), and carnosol (), respectively. It suggested that 10-carboxyl/formyl of abietane diterpenoids was essential for maintaining the antioxidative damage activity and the adjacent hydroxyl groups on the benzene ring was less important for holding the bioactivity. These acetylated derivatives with high bioactivity and stability could be regarded as new sources of antioxidants or antioxidative damage agents being used in the food and medical industry.
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