PMID:
Int J Prev Med. 2019 ;10:156. Epub 2019 Oct 9. PMID: 32133074
Abstract Title:
Antiproliferative and Anti-invasion Effects of Carvacrol on PC3 Human Prostate Cancer Cells through Reducing pSTAT3, pAKT, and pERK1/2 Signaling Proteins.
Abstract:
Background: One of the most effective parameters in the progression of the prostate cancer is interleukin (IL)-6 through affecting pSTAT3, pERK1/2, and pAKT cell signaling proteins. Carvacrol is an herbal antioxidant with antitumor effects. The purpose of this study was to investigate the effects of carvacrol ongene expression, pSTAT3, pAKT, pERK1/2 cellular signaling proteins, and invasion in human prostate cancer PC3 cells.Methods: PC3 cell viability was evaluated by MTT assay with different concentrations of carvacrol (0-800μM).gene expression and cellular concentration of pSTAT3, pERK1/2, and pAKT were investigated using the real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) and western blotting technic, respectively. PC3 cell invasion was determined by invasion assay test.Results: Carvacrol ICfor PC3 prostate cancer cells was 360μM. Carvacrol led to a significant reduction (
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