PMID:
Am J Cancer Res. 2020 ;10(4):1170-1181. Epub 2020 Apr 1. PMID: 32368393
Abstract Title:
V3 ameliorates colitis-associated tumorigenesis by modulating the gut microbiome.
Abstract:
spp., a common probiotic used as a dietary supplement, is good for the digestive system. However, its anti-cancer activity still remains unclear. In this study, we aim to examine the effect of,andon azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated cancer. Male ICR mice were injected with 10 mg/kg AOM and 2.5% DSS via drinking water, and then fed with different(1× 10CFU/day) for 14 weeks. The colonic tissues were collected for biomedical analysis, and gut microbiota profiling was detected by next generation high-throughput sequencing comparing to the 16S rRNA gene. We found that pretreatment with(Lac.ferm) significantly inhibits colonic tumor formation (
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