PMID:
Cardiovasc Ther. 2020 ;2020:4940673. Epub 2020 Apr 29. PMID: 32426036
Abstract Title:
Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational Studies.
Abstract:
Background: Hypertension is regarded as a major and independent risk factor of cardiovascular diseases, and numerous studies observed an inverse correlation between vitamin C intake and blood pressure.Aim: Our aim is to investigate the relationship between serum vitamin C and blood pressure, including the concentration differences and the correlation strength.Method: Two independent researchers searched and screened articles from the National Library of Medicine, Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP databases, and WANFANG databases. A total of 18 eligible studies were analyzed in the Reviewer Manager 5.3 software, including 14 English articles and 4 Chinese articles.Results: In the evaluation of serum vitamin C levels, the concentration in hypertensive subjects is 15.13 mol/L lower than the normotensive ones (mean difference = -15.13, 95% CI [-24.19, -6.06], and= 0.001). Serum vitamin C has a significant inverse relation with both systolic blood pressure (Fisher's = -0.17, 95% CI [-0.20, -0.15],
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