Vitamin D metabolism and signaling in the immune system.

PMID:  Rev Endocr Metab Disord. 2012 Mar ;13(1):21-9. PMID: 21845364 Abstract Title:  Vitamin D metabolism and signaling in the immune system. Abstract:  Vitamin D has emerged as a pleiotropic regulator of human physiology, and recent work has revealed that it has several roles in control of human immune system function. Vitamin D was originally characterized …

This reviews the potential mechanisms of vitamin D in promoting the innate immune response against infectious agents.

PMID:  Curr Opin Endocrinol Diabetes Obes. 2014 Dec ;21(6):431-6. PMID: 25354043 Abstract Title:  Vitamin D for infections. Abstract:  PURPOSE OF REVIEW: Current data clearly support an interaction of vitamin D with cells of the immune system apart from its regulatory role in calcium homeostasis. The discovery that immune cells express the vitamin D receptor and …

This reviews the essential roles of vitamin D in modulating the immune system and its protective effects in diverse infections.

PMID:  Clin Calcium. 2015 Mar ;25(3):359-65. PMID: 25716808 Abstract Title:  [Current Topics on Vitamin D. The effects of vitamin D on the immune system]. Abstract:  Various kinds of immune cells-including macrophages, dendritic cells, T cells and B cells- express the vitamin D receptor and 1α-hydroxylase (CYP27B1), the enzyme necessary for the conversion of circulating 25-hydroxyvitamin …

Non-classical mechanisms of transcriptional regulation by the vitamin D receptor.

PMID:  J Steroid Biochem Mol Biol. 2014 Oct ;144 Pt A:74-80. Epub 2013 Jul 30. PMID: 23911725 Abstract Title:  Non-classical mechanisms of transcriptional regulation by the vitamin D receptor: insights into calcium homeostasis, immune system regulation and cancer chemoprevention. Abstract:  Hormonal 1,25-dihydroxyvitamin D [1,25(OH)2D] signals through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription …

Vitamin d and its role in cancer and immunity: a prescription for sunlight.

PMID:  Nutr Clin Pract. 2007 Jun ;22(3):305-22. PMID: 17507731 Abstract Title:  Vitamin d and its role in cancer and immunity: a prescription for sunlight. Abstract:  Vitamin D has been recognized for more than a century as essential for the normal development and mineralization of a healthy skeleton. More extensive roles for vitamin D were suggested …

Exploring vitamin D signalling within skin cancer

PMID:  Clin Endocrinol (Oxf). 2020 Apr ;92(4):273-281. Epub 2020 Jan 16. PMID: 31889334 Abstract Title:  Exploring vitamin D signalling within skin cancer. Abstract:  Sunlight exposure of the skin is associated with both risks and benefits. On one hand, sunlight ultraviolet (UV) radiation can cause skin cancer through signature DNA mutations. On the other hand, it …

Targeted 25-hydroxyvitamin D concentration measurements and vitamin D3 supplementation can have important patient and public health benefits.

n/a PMID:  Eur J Clin Nutr. 2020 Mar ;74(3):366-376. Epub 2020 Jan 29. PMID: 31996793 Abstract Title:  Targeted 25-hydroxyvitamin D concentration measurements and vitamin Dsupplementation can have important patient and public health benefits. Abstract:  Over the past two decades, many studies reported the benefits of higher 25-hydroxyvitamin D [25(OH)D] concentrations for nonskeletal effects. Researchers found …

Regulation of immune response by S-1-propenylcysteine through autophagy-mediated protein degradation.

PMID:  Exp Ther Med. 2020 Feb ;19(2):1570-1573. Epub 2019 Dec 27. PMID: 32010341 Abstract Title:  Regulation of immune response by-1-propenylcysteine through autophagy-mediated protein degradation. Abstract:  Autophagy is a key event in cellular recycling processes due to its involvement in the intracellular degradation of proteins. It has been demonstrated that-1-propenylcysteine (S1PC), a characteristic sulfur compound in …

Garlic supplementation for 8 weeks resulted in significant improvements in oxidative stress in women with rheumatoid arthritis.

PMID:  Int J Clin Pract. 2020 Mar 11:e13498. Epub 2020 Mar 11. PMID: 32159257 Abstract Title:  A randomized, double-blind, placebo-controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis. Abstract:  AIM: Rheumatoid arthritis (RA), is a prevalent immune-inflammatory disease, which is …

Vitamin D deficiency increases severity of paclitaxel-induced peripheral neuropathy.

PMID:  Breast Cancer Res Treat. 2020 Apr ;180(3):707-714. Epub 2020 Mar 12. PMID: 32166478 Abstract Title:  Vitamin D deficiency increases severity of paclitaxel-induced peripheral neuropathy. Abstract:  PURPOSE: Approximately 25% of patients receiving weekly paclitaxel for breast cancer require treatment disruptions to avoid severe, irreversible peripheral neuropathy (PN). Vitamin insufficiencies are PN risk factors in many …

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