PMID: Medicine (Baltimore). 2019 May ;98(18):e15311. PMID: 31045767 Abstract Title: Progress in research on gold nanoparticles in cancer management. Abstract: INTRODUCTION: The rapid advancement of nanotechnology in recent years has fuelled burgeoning interest in the field of nanoparticle research, particularly its application in cancer management. At present, there seems to be heightened interest in the …
Author Archives: Taylor Mercado
There is increasing evidence to suggest mercurial body burden is related to skin disorders and autism as a result of prenatal mercury exposure.
PMID: Environ Int. 2007 Jan ;33(1):108-21. Epub 2006 Aug 17. PMID: 16914205 Abstract Title: Environmental mercury contamination in China: sources and impacts. Abstract: This review article focused on the current status of mercury (Hg) contamination in different ecological compartments in China, and their possible environmental and health impacts, focusing on some major cities. Mercury emission …
Gold nanoparticles disrupt tumor microenvironment.
PMID: Bioconjug Chem. 2019 Jun 19 ;30(6):1724-1733. Epub 2019 May 22. PMID: 31067032 Abstract Title: Gold Nanoparticles Disrupt Tumor Microenvironment – Endothelial Cell Cross Talk To Inhibit Angiogenic Phenotypes in Vitro. Abstract: It is currently recognized that perpetual cross talk among key players in tumor microenvironment such as cancer cells (CCs), cancer associated fibroblasts (CAFs), …
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Various forms of mercury, including thimerosal, are cytotoxic and apoptotic in vitro.
PMID: Toxicology. 2007 Feb 28 ;231(1):40-57. Epub 2006 Nov 25. PMID: 17210217 Abstract Title: Cell death and cytotoxic effects in YAC-1 lymphoma cells following exposure to various forms of mercury. Abstract: The effects of 1 min-4 h exposures to four Hg compounds (mercuric chloride [HgCl2], methyl mercuric chloride [CH3HgCl], p-chloromercuribenzoate [p-CMB] and thimerosal [TMS; ethylmercurithiosalicylate]) …
Gold nanoparticle uptake is enhanced by estradiol in MCF-7 breast cancer cells.
PMID: Int J Nanomedicine. 2019 ;14:2705-2718. Epub 2019 May 1. PMID: 31118607 Abstract Title: Gold nanoparticle uptake is enhanced by estradiol in MCF-7 breast cancer cells. Abstract: In the present study, we investigated the effects of 17β-estradiol (E) on membrane roughness and gold nanoparticle (AuNP) uptake in MCF-7 breast cancer cells.Estrogen receptor (ER)-positive breast cancer …
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Thimerosal can induce DNA damage in human conjunctival epithelial cells. Hyaluronic acid is protective against thimerosal-induced damage.
PMID: Graefes Arch Clin Exp Ophthalmol. 2012 Oct ;250(10):1459-66. Epub 2012 Jun 24. PMID: 22729468 Abstract Title: Cytoprotective effect of hyaluronic acid and hydroxypropyl methylcellulose against DNA damage induced by thimerosal in Chang conjunctival cells. Abstract: BACKGROUND: To investigate genotoxicity of the preservative thimerosal (Thi), and the cytoprotective and antioxidant effects of hyaluronic Acid (HA) …
Effect of gold nanoparticles treatment on the testosterone-induced benign prostatic hyperplasia in rats.
PMID: Int J Nanomedicine. 2019 ;14:3145-3154. Epub 2019 May 3. PMID: 31118628 Abstract Title: Effect of gold nanoparticles treatment on the testosterone-induced benign prostatic hyperplasia in rats. Abstract: Gold nanoparticles (AuNps) are promising agents for prostate cancer therapy. Herein, the in vivo effects of 20 and 50 nm sized AuNps on experimentally induced benign prostatic …
Thimerosal induces DNA strand breaks, downregulates glutathione, and stimulates apoptosis in vitro.
PMID: Chem Res Toxicol. 2008 Feb ;21(2):483-93. Epub 2008 Jan 16. PMID: 18197631 Abstract Title: Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase II alpha. Abstract: Thimerosal is an organic mercury compound that is widely used as a preservative in vaccines and other solution formulations. The use of thimerosal has caused …
This is a case study of a patient who developed a maculopapular rash following thimerosal-containing vaccine administration due to allergy.
PMID: Ann Allergy Asthma Immunol. 2005 Jan ;94(1):90-4. PMID: 15702823 Abstract Title: A generalized reaction to thimerosal from an influenza vaccine. Abstract: BACKGROUND: Thimerosal is a preservative commonly used in ophthalmic solutions, otic drops, and vaccines because of its bactericidal property.OBJECTIVE: To report a case of a generalized reaction to thimerosal in a patient who …
An alternatively spliced form of methionine synthase expressed in human neuronal cells is sensitive to inhibition by thimerosal and lower GSH levels contribute to their inhibitory action.
PMID: Oxid Med Cell Longev. 2016 ;2016:6143753. Epub 2016 Feb 18. PMID: 26989453 Abstract Title: Alternatively Spliced Methionine Synthase in SH-SY5Y Neuroblastoma Cells: Cobalamin and GSH Dependence and Inhibitory Effects of Neurotoxic Metals and Thimerosal. Abstract: The folate and cobalamin (Cbl-) dependent enzyme methionine synthase (MS) is highly sensitive to oxidation and its activity affects …
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