PMID: Cell J. 2020 Jan ;21(4):419-425. Epub 2019 Jul 29. PMID: 31376323 Abstract Title: The Use ofß-Elemene to Enhance Radio Sensitization of A375 Human Melanoma Cells. Abstract: Objective: Melanoma is the most malignant and severe type of skin cancer. It is a tumor with a high risk of metastasis and resistant to conventional treatment methods …
Author Archives: Taylor Mercado
The present review focuses on pre-clinical and clinical trials on curcumin supplementation in T2DM.
PMID: Nutrients. 2019 Aug 8 ;11(8). Epub 2019 Aug 8. PMID: 31398884 Abstract Title: Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment. Abstract: Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has reached pandemic dimensions all over the world. The multifactorial nature of the pathology makes patient management, which includes …
Perillaldehyde has a significant preventative and therapeutic effect on vaginal candidiasis.
PMID: Front Microbiol. 2019 ;10:1466. Epub 2019 Jul 2. PMID: 31333606 Abstract Title: Effect of Perillaldehyde on Prophylaxis and Treatment of Vaginal Candidiasis in a Murine Model. Abstract: Vulvovaginal candidiasis is a common fungal infection afflicting women which is primarily caused by the yeast(). It is imperative to introduce new drug classes to counter this …
Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption.
PMID: R Soc Open Sci. 2019 Jun ;6(6):190360. Epub 2019 Jun 12. PMID: 31312498 Abstract Title: Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts. Abstract: Osteoclasts are multinuclear giant cells that have unique ability to degrade bone. The search for …
Long-term pantethine treatment counteracts pathologic gene dysregulation and decreases Alzheimer’s disease pathogenesis.
PMID: Neurotherapeutics. 2019 Jul 2. Epub 2019 Jul 2. PMID: 31267473 Abstract Title: Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model. Abstract: The low-molecular weight thiol pantethine, known as a hypolipidemic and hypocholesterolemic agent, is the major precursor of co-enzyme A. We have previously shown that …
Root extract of Prunella vulgaris inhibits in vitro and in vivo carcinogenesis in MCF-5 human breast carcinoma.
PMID: J BUON. 2019 Mar-Apr;24(2):549-554. PMID: 31128004 Abstract Title: Root extract of Prunella vulgaris inhibits in vitro and in vivo carcinogenesis in MCF-5 human breast carcinoma via suppression of angiogenesis, induction of apoptosis, cell cycle arrest and modulation of PI3K/AKT signalling pathway. Abstract: PURPOSE: In this study we examined the anticancer effects of methanolic root …
Pterostilbene inhibits adipocyte conditioned-medium-induced colorectal cancer cell migration.
PMID: J Agric Food Chem. 2019 Aug 16. Epub 2019 Aug 16. PMID: 31419115 Abstract Title: Pterostilbene inhibits adipocyte conditioned-medium-induced colorectal cancer cell migration through targeting FABP5-related signaling pathway. Abstract: Pterostilbene (PTS) is a phenolic compound with diverse pharmacologic activities. However, its potential for inhibiting obesity-related CRC remains unclear. Our study evaluated the mechanism of …
Policosanol supplementation significantly improves blood pressure among adults
PMID: Complement Ther Med. 2019 Aug ;45:89-97. Epub 2019 May 23. PMID: 31331588 Abstract Title: Policosanol supplementation significantly improves blood pressure among adults: A systematic review and meta-analysis of randomized controlled trials. Abstract: BACKGROUND AND AIMS: Policosanol contains a mixture of concentrated primary aliphatic alcohols extracted from sugar cane wax and is recognized as a …
Continue reading “Policosanol supplementation significantly improves blood pressure among adults”
Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death.
PMID: J Asian Nat Prod Res. 2019 Jul 25:1-14. Epub 2019 Jul 25. PMID: 31345059 Abstract Title: Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death. Abstract: Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. Further investigation showed XN inhibited cell proliferation in a time- and …
Xanthohumol exhibits anti-myeloma activity in vitro.
PMID: Biochim Biophys Acta Gen Subj. 2019 Aug 3. Epub 2019 Aug 3. PMID: 31386885 Abstract Title: Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production. Abstract: BACKGROUND: Xanthohumol (XN, a hop-derived prenylflavonoid) was found to exert …
Continue reading “Xanthohumol exhibits anti-myeloma activity in vitro.”
Health Time 