PMID: Oxid Med Cell Longev. 2019 ;2019:4750795. Epub 2019 Jun 17. PMID: 31316718 Abstract Title: Biotransformation of Cranberry Proanthocyanidins to Probiotic Metabolites byEnhances Their Anticancer Activity in HepG2 Cells. Abstract: This study was designed to unravel the role ofin the bioconversion of cranberry proanthocyanidins and cytotoxicity of resulting metabolites to hepatocellular carcinoma HepG2 cells. Crude …
Author Archives: Taylor Mercado
Litchi flowers might have the potential to diminish the liver cancer risk in a nickel-contaminated environment through suitable treatment.
PMID: J Food Biochem. 2019 Jul ;43(7):e12882. Epub 2019 May 1. PMID: 31353727 Abstract Title: Litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction exhibited protective efficacy to suppress nickel-induced expression for vascular endothelial growth factor in HepG2 cells. Abstract: The protective efficacy of litchi (Litchi chinensis Sonn.) flower proanthocyanidin fraction (LFPF) composed of (-)-epicatechin and proanthocyanidin …
Grape-derived polyphenols produce antidepressant effects via VGF- and BDNF-dependent mechanisms.
PMID: Ann N Y Acad Sci. 2019 May 10. Epub 2019 May 10. PMID: 31074515 Abstract Title: Grape-derived polyphenols produce antidepressant effects via VGF- and BDNF-dependent mechanisms. Abstract: Recent studies suggest that bioactive dietary polyphenol preparation (BDPP) and individual polyphenolic compounds ameliorate stress-induced depression-like behaviors, but the underlying molecular mechanisms are incompletely understood. VGF (non-acronymic) …
Grape seed extract exhibited a protective effect in rats against oxidative stress, hyperlipidemia and hematological alterations induced by dexamethasone.
PMID: Indian J Clin Biochem. 2019 Apr ;34(2):213-218. Epub 2018 Feb 7. PMID: 31092996 Abstract Title: Grape Seed Extract Alleviates Dexamethasone-Induced Hyperlipidemia, Lipid Peroxidation, and Hematological Alteration in Rats. Abstract: The ameliorative effects of dietary natural compounds have drawn increasing attention. Dietary antioxidant is considered a common practice adopted in traditional and alternative medicine. The …
Grape seeds proanthocyanidin extract ameliorates Ehrlich solid tumor induced renal tissue and DNA damage in mice.
PMID: Biomed Pharmacother. 2019 Jul ;115:108908. Epub 2019 May 17. PMID: 31108378 Abstract Title: Grape seeds proanthocyanidin extract ameliorates Ehrlich solid tumor induced renal tissue and DNA damage in mice. Abstract: The current study was carried out to evaluate the protective effect of grape seed proanthocyanidins extract (GSPE) against Ehrlich solid tumor (EST) induced renal …
Oral grape seed proanthocyanidin extract therapy for 1 year improved hard exudates in patients with non-proliferative diabetic retinopathy.
PMID: Medicine (Baltimore). 2019 May ;98(21):e15515. PMID: 31124931 Abstract Title: Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy. Abstract: PURPOSE: To evaluate the efficacy and safety of orally administered grape seed proanthocyanidin extract (GSPE) in patients with non-proliferative diabetic retinopathy (NPDR).METHODS: In this randomized (1:2:2), multicentre, double-blind trial, …
Grape seed and skin extract acts at multiple levels to protect dopamine neurons from degeneration in a model of Parkinson’s disease.
PMID: Nutr Neurosci. 2019 May 25:1-15. Epub 2019 May 25. PMID: 31131731 Abstract Title: Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson's disease. Abstract: Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta, and it involves …
A pilot study of a grape seed procyanidin extract for lung cancer chemoprevention.
PMID: Cancer Prev Res (Phila). 2019 Aug ;12(8):557-566. Epub 2019 May 28. PMID: 31138523 Abstract Title: A Pilot Study of a Grape Seed Procyanidin Extract for Lung Cancer Chemoprevention. Abstract: Grape seed procyanidin extract (GSE) had been reported to exert antineoplastic properties in preclinical studies. A modified phase I, open-label, dose-escalation clinical study was conducted …
Grape seed extract could reduce clastogenic and cytotoxic effects of gamma irradiation in mice bone marrow cells.
PMID: J Cancer Res Ther. 2019 Jul-Sep;15(3):512-516. PMID: 31169212 Abstract Title: Radioprotective effect of grape seed extract against gamma irradiation in mouse bone marrow cells. Abstract: Introduction: Ionizing radiations produce free radicals which are often responsible for DNA damage or cell death. Grape seed extract (GSE) is a natural compound having an antioxidant that protects …
Pro-apoptotic effect of grape seed extract on MCF-7 cells.
PMID: Int J Mol Sci. 2019 Jul 2 ;20(13). Epub 2019 Jul 2. PMID: 31269652 Abstract Title: Pro-Apoptotic Effect of Grape Seed Extract on MCF-7 Involves Transient Increase of Gap Junction Intercellular Communication and Cx43 Up-Regulation: A Mechanism of Chemoprevention. Abstract: Growing evidence suggests dietary antioxidants reduce the risk of several cancers. Grape seeds extracts …
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