PMID: Food Chem Toxicol. 2019 May ;127:218-227. Epub 2019 Mar 22. PMID: 30910686 Abstract Title: Mitigating effects of apigenin on edifenphos-induced oxidative stress, DNA damage and apoptotic cell death in human peripheral blood lymphocytes. Abstract: Edifenphos (EDF) is an Organophosphorus pesticide and used in agriculture for pest control. However, EDF has been shown to accumulate …
Author Archives: Taylor Mercado
Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress.
PMID: Metab Brain Dis. 2019 Jun ;34(3):853-864. Epub 2019 Mar 27. PMID: 30919246 Abstract Title: Soursop fruit extract mitigates scopolamine-induced amnesia and oxidative stress via activating cholinergic and Nrf2/HO-1 pathways. Abstract: Current therapeutic interventions for memory loss are inadequate and are associated with numerous adverse effects. There is an urgent need for new alternative agents …
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The herein presented data suggest that N-acetylcysteine and alpha-lipoic acid may improve some deleterious effects of sexual hormone depletion.
PMID: J Nutr Biochem. 2019 May ;67:190-200. Epub 2019 Mar 10. PMID: 30951973 Abstract Title: N-acetylcysteine and alpha-lipoic acid improve antioxidant defenses and decrease oxidative stress, inflammation and serum lipid levels in ovariectomized rats via estrogen-independent mechanisms. Abstract: Sexual hormone deficiency has been associated with metabolic changes, oxidative stress and subclinical inflammation in postmenopausal women. …
Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation.
PMID: Drug Des Devel Ther. 2019 ;13:1155-1162. Epub 2019 Apr 11. PMID: 31043768 Abstract Title: Neuroprotective effect of-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation. Abstract: Background: Neurotoxicity is a major obstacle to the effectiveness of cisplatin (CDDP) in cancer chemotherapy. Oxidative stress and inflammation are considered to be …
N-acetylcysteine attenuates cisplatin-induced acute kidney injury by inhibiting the C5a receptor.
PMID: Biomed Res Int. 2019 ;2019:4805853. Epub 2019 Apr 14. PMID: 31111056 Abstract Title: -Acetylcysteine Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting the C5a Receptor. Abstract: N-acetylcysteine has been widely used as a nutritional supplement and drug in humans for its antioxidant properties. The complement activation fragment C5a is a strong proinflammatory molecule that mediates …
N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression.
PMID: Biogerontology. 2019 Aug ;20(4):533-543. Epub 2019 May 21. PMID: 31115735 Abstract Title: N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression. Abstract: N-Acetylcysteine (NAc) has been shown to play a diversity of favorable health-related roles (e.g., antioxidant, paracetamol antidote, mucolytics, neuroprotective agent). Having said that, here in this study, we evaluate the …
Efficacy and safety of N-acetylcysteine therapy for idiopathic pulmonary fibrosis.
PMID: Exp Ther Med. 2019 Jul ;18(1):802-816. Epub 2019 May 15. PMID: 31258714 Abstract Title: Efficacy and safety of-acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta-analysis. Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease with poor prognosis and limited treatment options.-acetylcysteine (NAC), an anti-oxidant drug, has …
“Antivaxxers Are Killers” Programmed Into Microsoft’s BING Autosuggest – Is this Hate Speech?
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N-acetylcysteine prevents bladder tissue fibrosis in a lipopolysaccharide-induced cystitis rat model.
PMID: Sci Rep. 2019 May 31 ;9(1):8134. Epub 2019 May 31. PMID: 31148586 Abstract Title: N-acetylcysteine prevents bladder tissue fibrosis in a lipopolysaccharide-induced cystitis rat model. Abstract: Therapeutic options for non-Hunner type interstitial cystitis (IC), which is histologically characterized by fibrosis and mast cell infiltration, are limited. We developed a rat model that replicates chronic …
NAC could be used as a therapeutic agent in addition to standard cisplatin treatment protocols.
PMID: Bratisl Lek Listy. 2019 ;120(6):423-428. PMID: 31223022 Abstract Title: The effects of N-acetylcysteine on cisplatin induced cardiotoxicity. Abstract: OBJECTIVES: Recent studies reported that oxidative stress is an important mechanism that contributes to cisplatin induced cardiotoxicity. In the present study, the effects of N-acetylcysteine (NAC), which is an antioxidant, on cisplatin induced cardiotoxicity were investigated …
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