PMID: J Neurochem. 2003 Jun ;85(5):1101-8. PMID: 12753069 Abstract Title: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. Abstract: Increased levels of a 40-42 amino-acid peptide called the amyloid beta protein (A beta) and evidence of oxidative damage are early neuropathological markers of Alzheimer's disease (AD). Previous …
Author Archives: Taylor Mercado
The melatonin immunomodulatory actions in radiotherapy
PMID: Biophys Rev. 2017 Apr ;9(2):139-148. Epub 2017 Mar 27. PMID: 28510090 Abstract Title: The melatonin immunomodulatory actions in radiotherapy. Abstract: Radiotherapy has a key role in cancer treatment in more than half of patients with cancer. The management of severe side effects of this treatment modality is a limiting factor to appropriate treatment. Immune …
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Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism.
PMID: Immunology. 1988 Mar ;63(3):465-9. PMID: 3350581 Abstract Title: Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Abstract: We have recently demonstrated that the pineal neurohormone melatonin exerts important immunoregulatory functions. We now report that exogenous melatonin counteracts completely the effect of acute …
Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care
PMID: Cell Death Dis. 2019 04 8 ;10(4):317. Epub 2019 Apr 8. PMID: 30962427 Abstract Title: Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care. Abstract: Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal gland in dark conditions and regulates …
Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases.
PMID: Int J Mol Sci. 2013 May 31 ;14(6):11742-66. Epub 2013 May 31. PMID: 23727938 Abstract Title: Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases. Abstract: Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal rhythms, and antioxidant …
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Melatonin and the immune system in aging.
PMID: Neuroimmunomodulation. 2008 ;15(4-6):272-8. Epub 2008 Nov 26. PMID: 19047804 Abstract Title: Melatonin and the immune system in aging. Abstract: Aging is associated with a decline in immune function (immunosenescence), a condition known to correlate with increased incidence of cancer as well as infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased …
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Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance.
PMID: Front Immunol. 2018 ;9:3160. Epub 2019 Jan 15. PMID: 30697214 Abstract Title: Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance. Abstract: It is well-established that the nutritional deficiency or inadequacy can impair immune functions. Growing evidence suggests that for certain nutrients increased intake above currently recommended levels may help optimize …
Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea.
PMID: Food Chem. 2012 Dec 15 ;135(4):2222-8. Epub 2012 Jul 15. PMID: 22980794 Abstract Title: Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM). Abstract: Immunosenescence, the progressive decline of adaptive immunity and chronic inflammation with ageing has been demonstrated to be the main factor responsible for …
Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells.
PMID: Int Immunopharmacol. 2018 Aug ;61:231-240. Epub 2018 Jun 9. PMID: 29894862 Abstract Title: Phytochemicals inhibit the immunosuppressive functions of myeloid-derived suppressor cells (MDSC): Impact on cancer and age-related chronic inflammatory disorders. Abstract: Traditional herbal medicine has provided natural remedies against cancers and many age-related inflammatory diseases for thousands of years. Modern drug discovery techniques …
Grape polyphenols corrects ageing-related detriments in neutrophil functionality via modulation of specific molecular targets.
PMID: Inflammopharmacology. 2018 Oct ;26(5):1349-1358. Epub 2018 Jun 27. PMID: 29951779 Abstract Title: Grape polyphenols corrects ageing-related detriments in neutrophil functionality via modulation of specific molecular targets. Abstract: Oxidative stress and inflammation are intricately interlinked as aetiological factors in the context of ageing and chronic disease-related accelerated ageing. Previous research by our group has highlighted …
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