Author Archives: Taylor Mercado

PMID:  Arch Pharm Res. 2011 May ;34(5):853-9. Epub 2011 Jun 9. PMID: 21656372 Abstract Title:  Antiarthritic effect of lonicerin on Candida albicans arthritis in mice. Abstract:  Fungal arthritis is a potentially serious disease resulting in rapid destruction of the joint. Among the various Candida species, Candida albicans is the most commonly associated with fungal arthritis. …

Continue reading “Antiarthritic effect of lonicerin on Candida albicans arthritis in mice.”

PMID:  Biochim Biophys Acta. 2015 Apr ;1851(4):446-55. Epub 2014 Nov 14. PMID: 25463478 Abstract Title:  Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic andα-linolenic acids; bioactivities and potential use as biomarkers. Abstract:  Cyclic oxygenated metabolites are formed in vivo through non-enzymatic free radical reaction of n-6 and n-3 polyunsaturated fatty acids (PUFAs) such as arachidonic …

Continue reading “This review outlines the bioactivity of certain oxidized fatty acids and mentions the anti-inflammatory, anti-atherogenic, and anti-arrhythmic effects of oxidized docosahexanoic acid (DHA) and eicosapentaenoic acid (EPA).”

PMID:  PLoS One. 2014 ;9(2):e89393. Epub 2014 Feb 18. PMID: 24558496 Abstract Title:  Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. Abstract:  The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized …

Continue reading “A lipid peroxidation product of DHA exerts anti-atherogenic properties and is a potential biomarker of DHA-associated atherosclerosis prevention.”

PMID:  PLoS One. 2013 ;8(7):e69415. Epub 2013 Jul 23. PMID: 23936010 Abstract Title:  4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. Abstract:  Recent studies have proposed that n-3 polyunsaturated fatty acids (n-3 PUFAs) have direct antioxidant and anti-inflammatory effects in vascular tissue, explaining their cardioprotective effects. However, the molecular mechanisms are …

Continue reading “A lipid peroxidation product of DHA exerts cardioprotective effects by activating endothelial Nrf2.”

PMID:  Free Radic Biol Med. 2015 Sep ;86:269-78. Epub 2015 Apr 21. PMID: 25911196 Abstract Title:  Nonenzymatic lipid mediators, neuroprostanes, exert the antiarrhythmic properties of docosahexaenoic acid. Abstract:  Neuroprostanes are lipid mediators produced by nonenzymatic free radical peroxidation of docosahexaenoic acid (DHA). DHA is associated with a lower atherosclerosis risk, suggesting a beneficial role in …

Continue reading “A lipid peroxidation product of DHA exerts anti-arrhythmia properties post heart attack in mice. It challenges the paradigm that all lipid peroxidation products are unconditionally toxic.”

PMID:  Free Radic Biol Med. 2017 01 ;102:229-239. Epub 2016 Dec 5. PMID: 27932075 Abstract Title:  Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F-neuroprostane protects the heart against reperfusion injury. Abstract:  Acute myocardial infarction leads to an increase in oxidative stress and lipid peroxidation. 4(RS)-4-F-Neuroprostane (4-F-NeuroP) is a mediator produced by non-enzymatic free radical peroxidation of the …

Continue reading “A lipid peroxidation product of DHA regulates mitochondrial homeostasis and reduces apoptosis to reduce reperfusion damage in a rat model of ischemic reperfusion.”

PMID:  J Clin Endocrinol Metab. 2016 09 ;101(9):3264-71. Epub 2016 May 18. PMID: 27192695 Abstract Title:  Increased F3-Isoprostanes in the Canadian Inuit Population Could Be Cardioprotective by Limiting F2-Isoprostane Production. Abstract:  CONTEXT: F3-isoprostanes (F3-IsoPs), derived from peroxidation of eicosapentaenoic acid (C20:5n-3), could be cardioprotective by limiting production of F2-isoprostanes (F2-IsoPs), a cardiovascular disease risk factor.OBJECTIVE: …

Continue reading “This study points out that the peroxidation products of eicosapentaenoic acid are anti-inflammatory and anti-thrombotic and, thus, cardioprotective.”

PMID:  J Ethnopharmacol. 2011 Oct 31 ;138(1):1-21. Epub 2011 Aug 16. PMID: 21864666 Abstract Title:  Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Lonicera japonica Thunb. (Caprifoliaceae), a widely used traditional Chinese medicine, was known as Jin Yin Hua (Chinese: ), Ren Dong and Japanese honeysuckle. It …

Continue reading “Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine.”

PMID:  Food Chem Toxicol. 2012 Mar ;50(3-4):797-807. Epub 2011 Dec 28. PMID: 22227216 Abstract Title:  Lonicera japonica THUNB. protects 6-hydroxydopamine-induced neurotoxicity by inhibiting activation of MAPKs, PI3K/Akt, and NF-κB in SH-SY5Y cells. Abstract:  In this study, we investigated the neuroprotective effects of Lonicera japonica THUNB. extract (LJ) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in SH-SY5Y cells. We …

Continue reading “These findings suggest that Lonicera japonica has a potent anti-parkinsonism effects.”

PMID:  Pharmacogn Mag. 2011 Oct ;7(28):284-8. PMID: 22262930 Abstract Title:  Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells. Abstract:  BACKGROUND: We previously reported that the extracts of several Korean medicinal plants showed neuroprotective activity in glutamate-injured primary culutres of rat cortical cells.OBJECTIVE: Among them, the effect of the …

Continue reading “Neuroprotective activity of the methanolic extract of Lonicera japonica in glutamate-injured primary rat cortical cells.”